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SM ISO690:2012 VASILACHE, Eugenia, CARACAŞ, Anastasia. Hepatotoxicitatea vitaminelor liposolubile A şi E. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 72. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Background. The share of drug-induced liver diseases, caused by fat-soluble vitamins used uncontrollably, varies from 2 to 20 percent. Vitamins A and E, along with the beneficial effects, can exert toxic action on the liver manifested by hepatitis, non-cirrhotic portal hypertension. Objective of the study. To analyze reports of hepatotoxicity of fat-soluble vitamins A and E and to characterize the clinical and paraclinical aspects of liver damage when using vitamin preparations with elucidation of the mechanisms underlying liver toxicity. Material and Methods. A clinical case of administration of AEVIT 15 capsules / day for 2 years was analyzed (doses of vitamin E 1500 IU / day and vitamin A 1500000 IU / day). Results. The patient was hospitalized with the accusations: embarrassment in the right hypochondrium and epigastrium, weakness, dry skin, hair loss, abdominal distension, peripheral edema. Examination found: sclera jaundice, hepatomegaly ( + 1.5 cm) and splenomegaly ( + 3 cm ) , moderate increase in aspartate aminotransferase and alkaline phosphatase , hypoalbuminemia, and liver elastography - signs of cirrhosis. Liver biopsy: focal lobular hepatitis and enlarged, lipid-laden, stellate cells with varying degrees of sinusoidal fibrosis. Abdominal ultrasonography: signs of extrahepatic portal hypertension and signs of nonalcoholic steatosis. Conclusion. Portal hypertension in hypervitaminosis A and E is caused by obstruction of the perisinusoidal spaces Disse as a result of hyperplasia and hypertrophy of stellate cells stimulated by lipid vacuoles in the cytoplasm with collagen production and the development of perisinusoidal fibrosis |
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Cuvinte-cheie Vitamin A, vitamin E, drug hepatitis, hypervitaminosis, vitamina A, vitamina E, hepatită medicamentoasă, hipervitaminoză |
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<?xml version='1.0' encoding='utf-8'?> <resource xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xmlns='http://datacite.org/schema/kernel-3' xsi:schemaLocation='http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd'> <creators> <creator> <creatorName>Vasilache, E.</creatorName> <affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation> </creator> <creator> <creatorName>Caracaş, A.</creatorName> <affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation> </creator> </creators> <titles> <title xml:lang='ro,en'>Hepatotoxicitatea vitaminelor liposolubile A şi E</title> </titles> <publisher>Instrumentul Bibliometric National</publisher> <publicationYear>2020</publicationYear> <relatedIdentifier relatedIdentifierType='ISBN' relationType='IsPartOf'></relatedIdentifier> <subjects> <subject>Vitamin A</subject> <subject>vitamin E</subject> <subject>drug hepatitis</subject> <subject>hypervitaminosis</subject> <subject>vitamina A</subject> <subject>vitamina E</subject> <subject>hepatită medicamentoasă</subject> <subject>hipervitaminoză</subject> </subjects> <dates> <date dateType='Issued'>2020</date> </dates> <resourceType resourceTypeGeneral='Text'>Conference Paper</resourceType> <descriptions> <description xml:lang='en' descriptionType='Abstract'><p>Background. The share of drug-induced liver diseases, caused by fat-soluble vitamins used uncontrollably, varies from 2 to 20 percent. Vitamins A and E, along with the beneficial effects, can exert toxic action on the liver manifested by hepatitis, non-cirrhotic portal hypertension. Objective of the study. To analyze reports of hepatotoxicity of fat-soluble vitamins A and E and to characterize the clinical and paraclinical aspects of liver damage when using vitamin preparations with elucidation of the mechanisms underlying liver toxicity. Material and Methods. A clinical case of administration of AEVIT 15 capsules / day for 2 years was analyzed (doses of vitamin E 1500 IU / day and vitamin A 1500000 IU / day). Results. The patient was hospitalized with the accusations: embarrassment in the right hypochondrium and epigastrium, weakness, dry skin, hair loss, abdominal distension, peripheral edema. Examination found: sclera jaundice, hepatomegaly ( + 1.5 cm) and splenomegaly ( + 3 cm ) , moderate increase in aspartate aminotransferase and alkaline phosphatase , hypoalbuminemia, and liver elastography - signs of cirrhosis. Liver biopsy: focal lobular hepatitis and enlarged, lipid-laden, stellate cells with varying degrees of sinusoidal fibrosis. Abdominal ultrasonography: signs of extrahepatic portal hypertension and signs of nonalcoholic steatosis. Conclusion. Portal hypertension in hypervitaminosis A and E is caused by obstruction of the perisinusoidal spaces Disse as a result of hyperplasia and hypertrophy of stellate cells stimulated by lipid vacuoles in the cytoplasm with collagen production and the development of perisinusoidal fibrosis</p></description> <description xml:lang='ro' descriptionType='Abstract'><p>Introducere. Ponderea afecțiunilor hepatice medicamentoase, cauzate de vitaminele liposolubile A şi E utilizate necontrolat, variază de la 2 la 20 la sută. Vitaminele A și E, de rând cu efectele benefice, pot exercita o acțiune toxică asupra ficatului manifestată prin hepatită, hipertensiune portală necirotică. Scopul lucrării. A identifica raportări de hepatotoxicitate a vitaminelor A şi E şi a caracteriza aspectele clinice şi paraclinice de lezare a ficatului la utilizarea preparatelor vitaminice cu elucidarea mecanismelor ce stau la baza toxicităţii asupra ficatului. Material și Metode. S-a analizat un caz clinic de administrare timp de 2 ani a preparatului AEVIT, 15 capsule/zi (doze de vitamina E 1500 UI/zi și vitamina A 1500000 UI/zi). Rezultate. La internare pacienta prezenta acuzele: jenă în hipocondrul drept și epigastru, slăbiciune, uscăciunea pielii, alopecie, distensie abdominală, edeme periferice. La examinare, s-a constatat: icterul sclerelor, hepatomegalie (+1,5cm) și splenomegalie (+3cm), creșterea moderată a aspartataminotransferazei şi fosfatazei alcaline, hipoalbuminemie, iar la elastografia hepatică – semne de ciroză. La biopsia ficatului: hepatită lobulară focală şi celule stelate lărgite, încărcate cu lipide, cu grade variabile de fibroză sinusoidală. La ultrasonografia cavității abdominale s-au constatat semne de hipertensiune portală extrahepatică şi semne de steatoză nonalcoolică. Concluzii. Hipertensiunea portală în hipervitaminoza A şi E este determinată de obturarea spațiilor perisinusoidale Disse în rezultatul hiperplaziei și hipertrofiei celulelor stelate stimulate de vacuolele lipidice din citoplasmă cu producerea de colagen și dezvoltarea fibrozei perisinusoidale.</p></description> </descriptions> <formats> <format>application/pdf</format> </formats> </resource>