Background: according to foreign data, metabolic disorders, up to the formed syndrome, affect up to 30% of the adult population, and in the elderly occur in more than 45% of cases. Materials and methods: 129 patients aged 29 to 50 years (average age 42.96±1.32 years), with the diagnosis of K053 chronic periodontitis in the generalized form of mild and moderate severity (in remission) with and without metabolic syndrome were studied. Thrombocyte morphology was studied by scanning electron microscopy. Results: The study of platelet structure of the main and control groups patients showed different results on the background of normal and equal number of cells, both in patients with periodontitis (subgroup “P+MS” and “P without MS”) and in representatives of the control group (249,6±8,3х109/l and 256,8±8,7х109/l respectively). In the main group, the total number of active platelet forms was 48.92±0.18%, which is half of the total number of cells (in percent), i.e., was almost equal to the number of platelets in the intact form (discocytes). Moreover, in “P + MS” subgroup this indicator was higher (53.93±0.21%) than in “P without MS” subgroup (45.92±0.18%). In contrast to the patients of the main group in the control group the sum of active platelet forms made up – 15,44±0,08 %, and the number of intact forms made up 84,56±0,06 %. Discussion: The obtained results are significant for the formation of more effective interdisciplinary interaction between dentists, physicians and endocrinologists, as well as for the understanding of the necessity to develop schemes of antithrombotic therapeutic effect in order to correct the existing disorders and prevent the development of the CCD and their complications in such patients, and to assess the effectiveness of such therapy.