Conversion disorder is one of the most mysterious diseases since it was first described as "hysteria" centuries ago. The term "conversion" comes from the observation that psychological distress is being converted into a physical symptom, such as loss of muscle control, blindness, deafness, seizures or even apparent unconsciousness (Schönfeldt-Lecuona C, Connemann BJ, Höse A, Spitzer M, Walter H, Der Nervenarzt 75:619-627, 2004). For soldiers in combat theater, operating in a stressful environment due to asymmetric warfare is a routine requirement. Staying alert is critical to situational awareness and readiness. The objective of this investigation is to identify and find solution pathways for conversion disorders in patients, so as to enhance combat alertness. The preliminary data presented here is consistent with some of the initial investigations by other physicians, viz. Sydenham, Charcot, Breuer, Shapiro, Freud and many others (Semke VY, Sketches about hysteria. Publishing House of Tomsk University, Tomsk, 2008). Much work remains to be done to resolve hysteria's enigma and conversion disorders, which still remain a mystery in approximately 16 % patients, notwithstanding many medical and technological advances. A brief discussion of regenerative nanotechnology based platforms to enhance brain-machine interface is introduced. This investigation is intended to enhance awareness of the subject matter in PTSD and mTBI patients, as well.