Nowadays the use of information systems increases significantly in different fields of activities. In almost sector such as research, education, finance, government, health care, manufacturing and business, information system is treat as a need and play a prominent role. In this context, implementation of information system in genebank is also needed. In genebank information plays a significant role in biodiversity conservation. We talk aboutex situ, in situ and on farm conservation. A proper information system is the key to effective utilization of a gene bank’s resources. Genebank information systems are computer-based systems that allow data retrieval, data capture, selection, sort, data processing, data analysis and data exchange (Abdallah Bari, 1999). Documentation system is represented by the interrelated database that is characterized by the capabilities of entering, searching, printing and managing the data of germplasm collections in a genebank. The genebank documentation systems need to be frequently refreshed with new and updated information from each genebank collection (and other information sources such as inventories of crop wild relatives). Is important to note, germplasm information should be more easily accessible for plant breeders, crop scientists and other users. Thus, it is possible to provide better access to the plant material. The lack of easy access to germplasm information remains an important bottleneck for utilization of plant genetic resources material (Dag T.F. Endresen, Knüpffer, 2012). Around the world there are more than 1750 genebankswith more than 130 large and medium-size genebank collections holding more than 10,000 accessions each (FAO, 2010). The genebank information systems varies between institutes, from poorly completed, noncomputerized lists to online databases incorporating descriptors, molecular data, photos, georeference data etc. The unified information system on plant genetic resources in Republic of Moldova – ReGen, has been developed in the Centre of Plant Genetic Resources of Moldova, in 2002. The main objective of ReGen is to integrate and monitor the available data on existing germplasme collections at the national level. This system covers a wide range of taxonomic, biological, ecological and geographical data. The structure and design of database correspond to the central objective: to facilitate handling and access to information regarding the entire process of plant genetic resources conservation. This system allows: input and checking of data; to store the information corresponding to the descriptors for ex situ, in situ, on farm conservation; availability of data for multiple analysis and use; to obtain the necessary information from database in the form of report, queries, and different graphical presentations; facilitate access to actual germplasm etc. The passport data is essential especially for documentation of accessions maintained in ex situ collections. The subsystem for in situ conservation is structured in six compartments - initial data, location and sample identity, molecular data, and gene bank localization that covers a wide range of taxonomic, biological, ecological and geographical data.Regarding on farm conservation is important to note that information consists of two parts: passport data and collecting data that is determined by following issues: identification and features of collecting place, sample identity, information about the cultivar’s donor, cultivar distribution and cultivation manner, geophysics site description, selection and storage of collecting materials, cultivar uses, gene bank localization. In genebank an efficient information system provides registration and exchange of data and allows rapid accessioning of new samples and location of samples in storage and will serve for other variety of needs.