Implementation of regional development policy in Republic of Moldova has gained special increase in 2010, becoming an imperative assumed for it. This imperative is done in the context of European integration, decentralization and equitable distribution of community development opportunities across the country. In prospect of European integration, regional development is reflected in the RM-EU Action Plan in the section „Regional and rural development”, and in the Association Agreement between the European Union and the Republic of Moldova, that will be signed by the end of May 2014, and, it provides for the establishment of relations in the areas of regional development and regional cross-border cooperation. A special attention is paid to the development of disadvantaged areas and territorial cooperation to enhance communication, exchange of information and experience between national, local and civil society. Effective collaboration with European partners through the issue of regional development contributes to sustainable economic development of the whole territory of the Republic of Moldova by reducing the imbalance in economic development of localities. This will have a beneficial impact on economic development, infrastructure and transport near the standard of living of the population of Republic of Moldova to the European average.