Creation of drought-resistant varieties of most crops currently assumes particular relevance in connection with the frequent droughts in the territory of the Republic of Moldova. It is known that drought resistance of plants is a complex trait, the manifestation of which depends on the actions and interactions of various genes and gene complexes. For tomatoes, as well as for other crops, creation of drought-resistant genotypes is a very important task, since most modern varieties cultivated in the production are characterized by the lack of drought resistance. The analysis of variability in size of pollen grains of tomato under conditions of osmotic stress showed that this method can be used successfully to identify the differences between genotypes for resistance to this factor and to screen the perspective forms.