Biochip (diagnostic sensor) is a microarray or a matrix covered by protein molecules, nucleic acids, biomacromolecules or biostructures using for a large number of simultaneous tests in one sample. The supportsfor biochips are polydimethylsiloxane and polymethyl- methacrylate, but these polymers are often not suitable for application in any organic medium. Currently, glass is usually common used for biochips manufacturing. The relative chemical inertness and the possibility of chemical modification do glass a convenient material and allow the molecule to consolidate on its surface. The immobilization of biomolecules on glass surface is possible after its chemical modifications – the formation of free silanol groups, followed the treatment with organic compounds to form reactive functional groups on the surface. The generation of micro-, nano- and macromolecular structures from organic substances with active functional groups (including organosilicon compounds) on the polymer surface allow to control the desired molecular structure and properties of surface layers [1, 2].formulaThe method of obtaining thiophene-phosphorus-nitrogen frameworks on a glass was developed. It was shown that such modifications exhibit hydrophilic properties compare the original surface. The obtained structure was studied by X-ray photoelectron spectroscopy and IR-spectroscopy.