The considerable increase in the number of exogenous and endogenous intoxications, diseases and pathological conditions, caused by the deplorable situation of the environmental conditions, is a very important issue of contemporary society. One of the most effective methods of detoxification of the human body is enterosorption based on the immobilization and elimination of toxins from the gastrointestinal tract. The most required enterosorbents are made from activated carbon derived from plant products, because their morphological structure favors the production of coals with high mechanical strength and increased adsorption capacity [1]. The performance (structural and adsorbent) qualities give these coals large opportunities for use in the treatment of intoxications and different pathologies [2]. With the prospect of use as enterosorbents, autochthonous activated carbons obtained from apple wood (CA-M 30) and nutshells (CA-N 30) were investigated. In order to obtain these active carbon samples, the physico-chemical process of activation was carried out in the laboratory under pilot conditions at 850^oC. The porous structure of the investigated activated carbon was determined from nitrogen adsorption isotherms (N2, 77 K) using the AUTOSORB-1 automated analyzer. In order to model intoxication situations with toxic substances, organic substances often serve as markers of exogenous and endogenous metabolites. For the purpose of studying the adsorption processes of small and medium molecular toxins (uremic toxins, methanol, ethanol etc), creatinine is used quite often, which is an indicator of renal function and monitoring its concentration within 24 hours can provide information about overall renal function. For the determination of creatinine, the method proposed by Jaffe (1972) in the modification of Beckman (1986) was used. The adsorption processes were investigated under static conditions at 22°C after the equilibrium of the process was established. The contact time of the creatinine solution with the examined active carbon samples was determined from the curve of the adsorption kinetics. Thus, it was found that during the first hour of contact time of the total amount of creatinine (Co = 100 mg/L) about 50% is immobilized, after six hours - almost 75% and 24 hours were sufficient for the balance of the adsorption process. The adsorption capacity of the adsorbed carbonate towards creatinine was determined from their adsorption isotherms. It was determined that the maximum active carbon adsorption values studied were 58 mg/g for charcoal obtained from apple wood and about 67 mg/g for coal from nut shells. The obtained data allow concluding that the investigated carbonate adsorbents obtained from the vegetable raw material are able to absorb endogenous metabolic products, like creatinine and are of interest for their use as enterosorbents.