Transition metal complexes with ONS donor Schiff bases are of particular interest due to their unusual configurations, structural lability, interesting magnetic properties and use as functional materials. Many d-metal complexes of aromatic Schiff bases are described as catalysts due to their sensitivity to molecular environments [1]. Here we report the synthesis of a new tetranuclear coordination compound of copper(II), using bis-thiosemicarbazone of2,6–diformyl-4-methylphenol (H3L) as a chelating ligand. The Schiff base ligand (H3L) was synthesized by the method described in literature [2]. The Cu(II) coordination compound with the composition [Cu4(L)2(DMSO)2(H2O)2]SO4have been investigated by IR, TGA, and X-ray crystallography. According to single–crystal X-ray diffraction studies, the core of this coordination compound is formed by a slightly distorted cubic tetranuclear cluster. The triply deprotonated ligand molecules adopt a planar conformation, using for coordination a S-O-S donor set of atoms (Figure). The DMSO molecules were neither coordinated to metal ions nor hydrogen bonded to the ligand. The complex [Cu4(L)2(DMSO)2(H2O)2]SO4 crystallizes in P-1 space group, with the following unit cell parameters: a=12.2571, b=14.4261, c=15.6373 A and a = 92.679(15), a=107.796(16) and b=115.140(15) °. Thermogravimetric and magnetic investigations of this compound will be also discussed.