Synthesis and antifungal properties of new copper (II) complexes with n-cyclohexyl-2-[(pyridin-2-yl) methylidene] hydrazine-1-carbothioamide
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2023-11-13 09:32
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NICOLENCO, Nicoleta, RUSNAC, Roman, BURDUNIUC (POPA), Olga, TSAPKOV, Victor I., GULYA, Aurelian. Synthesis and antifungal properties of new copper (II) complexes with n-cyclohexyl-2-[(pyridin-2-yl) methylidene] hydrazine-1-carbothioamide. In: Achievements and perspectives of modern chemistry, 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: Tipografia Academiei de Ştiinţe a Moldovei, 2019, p. 134. ISBN 978-9975-62-428-2.
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Achievements and perspectives of modern chemistry 2019
Conferința "International Conference "Achievements and perspectives of modern chemistry""
Chişinău, Moldova, 9-11 octombrie 2019

Synthesis and antifungal properties of new copper (II) complexes with n-cyclohexyl-2-[(pyridin-2-yl) methylidene] hydrazine-1-carbothioamide


Pag. 134-134

Nicolenco Nicoleta1, Rusnac Roman1, Burduniuc (Popa) Olga2, Tsapkov Victor I.1, Gulya Aurelian1
 
1 Moldova State University,
2 National Agency for Public Health
 
Disponibil în IBN: 7 noiembrie 2019


Rezumat

Thiosemicarbazone derivatives have attracted considerable attention in the past few decades, because of their potential physical, chemical, and biological properties. The heterocyclic NNS ligands play an important role in the development of coordination chemistry as they readily form complexes with most of metal ions. The first studies of coordination compounds of N-cyclohexylthiosemicarbazones with biometals were carried out by American researcher Douglas X. West who reportedabout this synthesis.Attention has been focused on pyridin-2-yl thiosemicarbazones, particularly on their coordination compounds with biometalsregarding biological properties such as antibacterial, antiparasitic and antitumoral [1]. N-cyclohexyl-2-[(pyridin-2-yl)methylidene]hydrazine-1-carbothioamide (HL) was synthesized according to the literature method [2] with some adjustments, resulting in a good yield. The condensation was performed by stirring (and warming) a solution of cyclohexylthiosemicarbazide (prepared by gently refluxing an excess of hydrazine monohydrate with cyclohexylisothiocyanate in ethanol) with 2-formylpyridine. The reaction was catalyzed by 3 drops of glacial acetic acid.All organic compounds were confirmed by thin layer chromatography, melting point, FTIR spectra and nuclear magnetic resonance 1H and 13C spectra.All complexes were synthesized by refluxing HL with the corresponding copper salt in ethanol in a molar ratio of 1:1. The obtained compounds were analyzed by FTIR spectroscopy and based on the results the substituted thiosemicarbazone coordinates through azomethine-N, pyridine-N, and thiolato-S.Table. Antifungal activity of Cu (II) coordination compoundsConclusion: Four new copper (II) complexes with N-cyclohexyl-2-[(pyridin-2yl)methylidene] hydrazine-1-carbothioamide (HL) have been synthesized. The complexes were found to be active against fungi, all compounds exhibitinhibit in the range of 0.03-15.62 mg/mL which is 2-1067 times more active than Nystatin.