CHITOSAN – a versatile platform for biomedical applications. II. CHITOSAN-based scaffolds for tissue engineering
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2022-06-03 11:14
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DUCEACA, Ioana Alexandra, TANASA, Fulga. CHITOSAN – a versatile platform for biomedical applications. II. CHITOSAN-based scaffolds for tissue engineering. In: Achievements and perspectives of modern chemistry, 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: Tipografia Academiei de Ştiinţe a Moldovei, 2019, p. 63. ISBN 978-9975-62-428-2.
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Achievements and perspectives of modern chemistry 2019
Conferința "International Conference "Achievements and perspectives of modern chemistry""
Chişinău, Moldova, 9-11 octombrie 2019

CHITOSAN – a versatile platform for biomedical applications. II. CHITOSAN-based scaffolds for tissue engineering


Pag. 63-63

Duceaca Ioana Alexandra1, Tanasa Fulga2
 
1 University of Medicine and Pharmacy “Grigore T. Popa”, Iasi,
2 “Petru Poni” Institute of Macromolecular Chemistry
 
Disponibil în IBN: 4 noiembrie 2019


Rezumat

Immunologic basis of the mechanisms of the graft rejection are not yet fully revealed, despite the scientific progress in the field, and regardless of the form of transplant, although it has been shown that allotransplantation elicited the lowest immune response [1,2]. Such shortcomings can be circumvented by using the pacient’s own cells/tissue or biodegradable artificial materials. In the latter case, the selected materials must be able to promote the neighboring cells proliferation or to act as scaffolds where the transplanted cells will adhere, proliferate and specifically differentiate under local physiological conditions. There is a wide variety of scaffolds made of polymeric biomaterials able to encapsulate cells, mitigate immune responses and regeneration of different types of tissue, or act as a barrier between tissues [3], and their key feature is the ability to interact with human living tissues while arousing no or minimal immune reaction. An in-depth insight of their biocompatibility may be achieved by understanding the fine bio-chemical and -physical mechanisms of the phenomena that occur during the interaction between the biomaterial and the living cells [4,5]. Among the naturally derived biomaterials (such as decellularized ECM, alginates, collagen, elastin, pullulan etc.), chitosan proved to be one of the most versatile natural biopolymers and its use in tissue engineering was motivated by the good biocompatibility, low cytotoxicity, and its ability to mediate the transfer of biologically active compounds or living cells between a scaffold and the host tissue. Chitosan-based in situ gels are already known as smart biomaterials in the regenerative medicine. The typical chitosan-based in situ gelling reaction systems and the corresponding mechanisms will be presented herein, as well as some of their special applications in tissue engineering.