Articolul precedent |
Articolul urmator |
702 3 |
Ultima descărcare din IBN: 2023-10-19 11:58 |
SM ISO690:2012 PETRENKO, Peter A., CHUMAKOV, Yurii, USATAIA, Irina, GRAUR, Vasilii О., POIRIER, Donald, TSAPKOV, Victor I., GULYA, Aurelian. The crystal structures and biological activity of methyl N'-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)carbamohydrazonothioate and methyl N'-[(2-hydroxynaphthalen-1-yl)methylidene]-N-(prop-2-en-1-yl)carbamohydrazonothioate. In: Materials Science and Condensed Matter Physics, Ed. 8-th Edition, 12-16 septembrie 2016, Chişinău. Chişinău: Institutul de Fizică Aplicată, 2016, Editia 8, p. 172. ISBN 978-9975-9787-1-2. |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Materials Science and Condensed Matter Physics Editia 8, 2016 |
|||||||
Conferința "International Conference on Materials Science and Condensed Matter Physics" 8-th Edition, Chişinău, Moldova, 12-16 septembrie 2016 | |||||||
|
|||||||
Pag. 172-172 | |||||||
|
|||||||
Descarcă PDF | |||||||
Rezumat | |||||||
Isothiosemicarbazones have been attracting attention of the researchers for a number of years, due to their interesting physicochemical and structural characteristics, as well as of biological properties. The aim of this work is the synthesis of salicylaldehyde (I) and 2-hydroxy-1-naphtaldehyde (II) 4-allyl-S-methylisothiosemicarbazones, determination of their structure and biological properties. For achieving these objectives 4-allylthiosemicarbazide was alkylated with iodomethane. After that, the corresponding aldehyde was added to the reaction medium. The resulting hydroiodide of 4-allylS-methylisothiosemicarbazone was neutralized with sodium carbonate. Crystals suitable for X-ray analysis were obtained by recrystallization in ethanol. In C=N-NH-CS backbones of I and II the S atoms are in trans and cis positions to azomethine N atoms respectively. These cores of the studied ligands are essentially planar to within 0.009 and 0.026 Ǻ. In I and II the dihedral angles of aromatic rings with mentioned backbones are equal to 2.4 and 2.2° respectively. The solvent molecule and hydroiodide join I in 3D-hydrogen-bonded network (Fig. 1a), while the N-H…O hydrogen bonds link molecules of II into 1D-chains along [010] direction (Fig. 1b) The synthesized compounds selectively inhibit the human promyelocytic leukemia HL-60 cells growth in the range of concentration 10-5-10-7 mol/L. This work was fulfilled with the financial support of the Institutional Project 15.817.02.24F. |
|||||||
|