Prosthetic poly (methyl methacrylate) is widely used for medical applications like lenses and eye prostheses. For prosthetic products biocompatibility is essential, different methods have been developed to control it by controlling surface wettability property. This article is targeted to describe a possible simple solution how to influence alterations of PMMA wettability by non-ionizing UV radiation in range of 200400nm. Processed material was examined by means of detecting contact angle, electron work function and absorption spectra to find correlation between wettability and other surface properties. Results show nonlinear tendency of surface wetting alteration and peculiarities in electron work function and absorption spectras. UV radiation could be used to functionalize PMMA surface by not influencing its structure with UV exposures under 60 minutes.