Clinical and immunological efficacy of conjugated pneumococcal vaccine in children with compensated chronic tonsillitis
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ABABIY, Ivan; DANILOV, Lucian; GINDA , S.; MANYUK, Mihail; ABABII, Polina; KOSTINOV, Mikhail. Clinical and immunological efficacy of conjugated pneumococcal vaccine in children with compensated chronic tonsillitis. In: Pediatriya - Zhurnal im G.N. Speranskogo. 2018, nr. 2(97), pp. 134-139. ISSN 0031-403X.
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Pediatriya - Zhurnal im G.N. Speranskogo
Numărul 2(97) / 2018 / ISSN 0031-403X

Clinical and immunological efficacy of conjugated pneumococcal vaccine in children with compensated chronic tonsillitis


DOI: 10.24110/0031-403X-2018-97-2-134-139
Pag. 134-139

Ababiy Ivan1, Danilov Lucian1, Ginda S.2, Manyuk Mihail1, Ababii Polina1, Kostinov Mikhail34
 
1 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
2 Institute of Phtysiopneumology „Chiril Draganiuc”,
3 I. I. Mechnikov Research Institute for Vaccines and Sera,
4 Sechenov First Moscow State Medical University
 
Disponibil în IBN: 24 iunie 2019


Rezumat

The article presents results of conjugated pneumococcal vaccine use in combination with basic therapy in 64 children with chronic compensated tonsillitis. The study showed that vaccination assists activation of T-lymphocytes subpopulation, increases sensitization to bacterial antigens, normalization of proinflammatory cytokines content, which is clinically manifested in a significant decrease in acute respiratory infections incidences and antibacterial therapy courses for 2 years after vaccination compared to patients receiving a traditional therapy course.

Cuvinte-cheie
Cellular immunity, children, chronic tonsillitis, Conjugated pneumococcal vaccine, Markers of inflammation