Natural Forest Reservations (NFR) are protected territory categories that have the objective to assure optimal conditions for the protection and reestablishment of the plant species, vegetal communities that are nationally significant. In the Republic of Moldova there are 51 objects that have the status of Natural Forest Reservation and are taken under the State’s protection. In the study are included 22 Natural Forest Reservations, which are geographically located in Danube’s Basin (Republic of Moldova). The investigated areas are located in the forest fund that creates favorable conditions for growth and development of a rich flora diversity. As a result, it was found that the investigated objects are characterized by a satisfactory ecologic condition and contain a rich diversity of rare species of flora. For some of the identified species, the evaluated areas serve as new habitats. The obtained results serve as scientific support for proving the protection category of the investigated objects, filling up the Ecologic Passports and the Database regarding the Cadastre of the State Natural Protected Areas.