Large-scale network architecture and associated structural cortico-subcortical abnormalities in patients with sleep/awake-related seizures
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CHIOSA, Vitalie; CIOLAC, Dumitru; GROPPA, Stanislav; KOIRALA, Nabin; PINTEA, Bogdan; VATAMAN, Anatolie; WINTER, Yaroslav; GONZALEZ-ESCAMILLA, Gabriel; MUTHURAMAN, Muthuraman; GROPPA, Sergiu. Large-scale network architecture and associated structural cortico-subcortical abnormalities in patients with sleep/awake-related seizures. In: Sleep. 2019, nr. 4(42), p. 0. ISSN 0161-8105.
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Sleep
Numărul 4(42) / 2019 / ISSN 0161-8105

Large-scale network architecture and associated structural cortico-subcortical abnormalities in patients with sleep/awake-related seizures


DOI: 10.1093/sleep/zsz006
Pag. 0-0

Chiosa Vitalie123, Ciolac Dumitru123, Groppa Stanislav32, Koirala Nabin1, Pintea Bogdan4, Vataman Anatolie2, Winter Yaroslav1, Gonzalez-Escamilla Gabriel1, Muthuraman Muthuraman1, Groppa Sergiu23
 
1 Universitatea Johannes Gutenberg din Mainz,
2 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
3 Emergency Medicine Institute,
4 BG University Hospital of Bochum
 
Disponibil în IBN: 19 aprilie 2019


Rezumat

Study Objectives In this study, we aimed to estimate the alterations of brain networks and structural integrity linked to seizure occurrence during sleep and awake states. Methods Using a graph theory approach to magnetic resonance imaging-derived volumes of cortical and subcortical regions, we investigated the topological organization of structural networks in patients with sleep seizures (n = 13), patients with awake seizures (n = 12), and age- A nd sex-matched healthy controls (n = 10). Abnormalities in regional structural substrates (cortical volume/surface area, subcortical volumes) associated with sleep seizures and awake seizures were further analyzed. Results Brain networks in patients with sleep seizures compared to patients with awake seizures displayed a more integrated structural organization coupled with greater networks' stability. When compared to healthy controls, networks in both patients with sleep and awake seizures were analogously compromised, exhibiting a less integrated and preserved organization. Patients with sleep seizures in contrast to awake seizures had larger volumes of bilateral insula, superior temporal, and orbitofrontal cortices but lower volumes of left postcentral and right middle temporal cortices in comparison to healthy controls. Patients with awake seizures compared to healthy controls displayed reduced volumes mainly in frontal, temporal, and parietal regions of right hemisphere. Volumes of hippocampus, amygdala, caudate, pallidum, and putamen were larger in patients with sleep seizures than in patients with awake seizures. Conclusions Despite epileptogenesis, patients with sleep and awake seizures had distinct network and structural correlates across different epilepsy types. Identified regional cortical/subcortical abnormalities can endorse the pathophysiological alterations that induce seizures during the sleep or awake states.

Cuvinte-cheie
awake seizures, network topology, sleep seizures, structural correlates