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SM ISO690:2012 MISCO, Anastasia, CAZACU (ANGHEL), Lilia, DUKA, Gh.. The influence of tartaric acid on conformation and stability of human serum transferrin. In: Ecological and environmental chemistry : - 2017, Ed. 6, 2-3 martie 2017, Chișinău. Chisinau, Republic of Moldova: Academy of Sciences of Moldova, 2017, Ediția 6, p. 216. |
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Ecological and environmental chemistry Ediția 6, 2017 |
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Conferința "Ecological and environmental chemistry 2017" 6, Chișinău, Moldova, 2-3 martie 2017 | |||||
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Pag. 216-216 | |||||
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Human transferrin is a glycoprotein from the protein family of the transferrin type composed of a single polypeptide chain consisting of approximate 700 amino acids with a molecular weight of 80kDa (pdb entry 3QYT). Each transferrin molecule has two active sites where the iron is bound through four amino acids: one aspartic acid, two tyrosine molecules and one histidine. Iron is an essential element for life, necessary for hemoglobin synthesis, proliferation and maturation of erythrocytes and is used by microorganisms to survive and replicate. It is also a key element for many germs. The iron uptake by human transferrin makes this element inaccessible for pathogenic microorganism, preventing them from further development. In unbounded state, iron catalyzes the reaction of formation of free radicals, which generate many harmful biochemical processes. Thus, iron binding by transferrin has an indirect role in the protection of living organism from oxidative stress (an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage). This interaction process of human transferrin and iron can be influenced by presence of compounds called chelating agents that can reduce or increase serum iron levels. Currently there is a little information about chelating agents effect on iron-binding ability of human transferrin described in literature, the effect of tartaric acid hasn’t been studied at all. The study results may serve as a guide to further research of the issue in biomedical and pharmaceutical domains (new drugs production). The influence of tartaric acid on the iron-binding properties of the human transferrin was investigated using the UV-Vis spectrophotometric titration method, in the pH range 3 – 8. |
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