Chlorinated aromatic hydrocarbons (CAH)–chlorinated benzenes and toluenes comprise a large spectrum of compounds that are enormous industrial and economic importance because of their applications and global outputs. Therefore, chloro-chemistry pushes into the focus of considerable debate and governmental regulatory action. In this respect, studies devoted eco-friendly disposal of CAH pollutants through heterogeneous oxidation in the presence of mixed oxides based on vanadia species supported on different supportants was reviewed. Oxovanadium systems modified by P, Mo, Co supported on Al2O3 were prepared by the impregnation, mechanical-chemical shifting co-precipitation techniques and characterized by Scanning Electron Microscopy (SEM), FT-IR, Thermal analysis, N2 adsorption/desorption and X-ray powder diffraction (XRD). These catalysts used for carrying out heterogeneous catalytic oxidation reactions of chlorinated aromatic hydrocarbons to chloromaleic anhydride (CMA). We investigated the effects of reaction temperature, reaction time, catalyst amount, mole ratio of initial CAH and oxygen on the reaction. Under optimal reaction condition, CAH conversion and CMA selectivity are respectively 66–91% and 21–33%. Likewise, both the disposal of ecological harmful substance and the synthesis of very important greener and safer raw materials (maleic anhydride and its chloro analogues benzaldehydes,) have been explored.