Stroke (AVC) is a major emergency and an important public health problem for Moldova, characterized by very high morbidity and mortality. From the many etiologic factors favouring this disease an important but less studied role bears the indices of drinking water quality. The study aimed to diagnose the indices of water quality impacting in triggering stroke (CVA). Materials and methods: For achieving the goal there were taken and investigated 120 water samples on 11 sanitary-chemical indicators from the nearby residences of stroke patients included in the study and there were selected individuals from the control group, which did not crash. Results and discussion: After evaluation of obtained data, we found that the highest non-compliance in researched water was recorded at parameters of water mineralization (dry residue, sulphates, nitrates and total hardness). Assessing the average values of the main indicators of water mineralization, which directly or indirectly may have an impact in the etiology of cerebrovascular diseases, including stroke, we found that the average of fixed residue, parameter that determines the overall level of mineralization of water, recorded the highest values in the sources that feed control group. The same regularity was typical for the concentration of sulphates and chlorides. The average level of total hardness, which many authors ascribe the protective role for cerebrovascular disease, presented the higher values also in water used by people who didn’t AVC (31.8 0G), where the estimated index was 2.8 times higher compared with control group. Conclusion: In the result of conducted study it was demonstrated the protective role of the degree of mineralization of drinking water in the cause of stroke.