In recent years, some ingested pharmaceutical compounds and their metabolites were detected in the surface and ground water situated near the sewage water treatment plants (STP). The non-steroidal anti-inflammatory drugs (NSAID) are special group of pharmaceuticals that are prescribed for muscle pain and inflammatory rheumatic disorders. The usage of these drugs is expected to increase in future. Paracetamol one of the non-steroidal anti-inflammatory drugs, is categorized as a pharmaceutically active compound. Prolonged exposure to these chemicals is expected to affect the health. This study aims to mineralize of paracetamol by anodic oxidation employing graphite and RuO2/IrO2/IrO2 coated titanium anode. The effect of process variables, such as initial pH, applied current density, processing time, type of electrolytes and its concentration were studied on the degradation of paracetamol. Chemical parameters such as chemical oxygen demand and total organic carbonwere analyzed for the efficiency of the process and UV-vis spectrophotometer and HPLC and GC-MS measured to confirm the degradation. Based on the study to degradation mechanism was proposed.