Fluoroquinolones are synthetic antibacterial agents of broad action spectrum for peroral administration. Because of heavy use, fluoroquinolones get into the environment through waste waters, biomass, compost, animal waste and they can cause serious harm to flora and fauna of water reservoirs even at their extremely low concentrations. Development of improved methods of fluoroquinolones oxidation, leading to their transformations in aqueous medium, is an important task of modern chemistry. In present work there has been studied the kinetics of oxidation of two fluoroquinolones (FQ) antibiotics representatives – ofloxacin (OF) and ciprofloxacin (CF) by ions in aqueous solutions in basic medium. There was used photometric method, with the aid of which there was measured the absorbance of reaction mixture at different time points, at  = 525 nm, corresponding to maximum of permanganate ions absorption. According to the low of mass action, the reaction rate of both reactions can be expressed as follows: , (1) where k is the reaction rate constant; n1 , n2, n3 –reaction orders on , FQ (OF or CF) and , correspondingly. If and , then it can be considered that during the reaction [FQ] = const and and equation (1) can be written as (2) where kobs is the observed constant, equal to (3) For the determination of the reaction orders on ions, each of both reactions was carried out at five different initial concentrations of and constant concentrations of FQ and providing that and . On the basis of the obtained data there were plotted dependences (At, and A∞ - the absorbance of the reaction mixture at the time t, and, respectively, residual absorbance), which presented straight lines with negative slope, consequently it was concluded that the reaction order on ions was equal to = 1 in the case of both antibiotics. For the determination of the reaction orders on OF, CF and ions, the reactions were carried out at constant concentration of and different concentrations of OF, and CF, (providing that and ). From graphic dependences there were determined the values of the observed constant kobs. On the basis of the obtained data there were plotted graphic dependences , and ), and from the slope of the obtained straight lines there were determined the reaction orders on OF, CF and ions. It has been determined that in the case of OF oxidation the reaction order on OF is 0, 62 and the reaction order on is 0, 18. In the case of CF oxidation it has been determined that the reaction orders on CF and are also less than 1.