Bioassay and estimation of the toxicity of metalorganic compounds impacting the population of paramecium caudatum
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TODERASH, Ion, GULYA, Aurelian, ROSCOV-ARCAN, Elena, GARBUZ, Olga. Bioassay and estimation of the toxicity of metalorganic compounds impacting the population of paramecium caudatum. In: Ecological and environmental chemistry : - 2017, Ed. 6, 2-3 martie 2017, Chișinău. Chisinau, Republic of Moldova: Academy of Sciences of Moldova, 2017, Ediția 6, p. 91.
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Ecological and environmental chemistry
Ediția 6, 2017
Conferința "Ecological and environmental chemistry 2017"
6, Chișinău, Moldova, 2-3 martie 2017

Bioassay and estimation of the toxicity of metalorganic compounds impacting the population of paramecium caudatum


Pag. 91-91

Toderash Ion1, Gulya Aurelian2, Roscov-Arcan Elena2, Garbuz Olga2
 
1 Academy of Sciences of Moldova,
2 Moldova State University
 
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Disponibil în IBN: 8 martie 2019


Rezumat

The work is dedicated to the study of some groups of organometallic substances and their impact on aquatic organisms. It is used the method of toxicological bioassay of coordination compounds CMT-28 and CMA-18, which influence the Paramecium caudatum Ehrnbg ciliate in concentrations of 100, 10, 1, 0.1, 0.01 uM / L, compared to the prototype. Infusoria Paramecium caudatum is one of the most commonly used test-objects in laboratory research aimed at directly determining the toxicity of chemical compounds, which are used in toxicological medicine and ecotoxicological control. The activity of substances has been evaluated after the character of toxicity of preparations (LT50 and LC50) and the activity of ciliated has been studied after the character of their viability and reproductive parameters (increasing or decreasing their numbers and reproductive rate). The obtained experimental results regarding the reproductive peculiarities of invertebrates have been systematized. It has been shown that coordination compounds CMT-28 and CMA-18 at concentrations of 100 and 10 uM/L inhibit totally the growth and division of infusoria (Figure 1). Figure 1. Inhibition of the Paramecium caudatum culture viability under the influence of coordination compounds CMT-28 and CMA-18. As it results from the analysis of experimental data, within the concentrations of 1 to 0.01 uM/L the compounds CMT-28 and CMA-18 have a toxic activity relative to the Paramecium caudatum laboratory organisms, inhibiting partly the reproductive parameters of ciliated. In the concentration range 0.01-10 UML, the values LC50 (lethal concentration, 50%) and LT50 (lethal time, 50%) have been calculated for substances CMT-28 and CMA-18. Thus, it has been obtained LC50 = 0.46 uM/L for CMA-28 and LC50 = 1.19 uM/L for CMT-18. Hence, the CMA-18 is less toxic compared to CMT-28. The lethal time, LT50, for the CMA-18, at the concentration of 1 uM/L, is the 3rd day, and LT50 for CMT-28 at the concentration of 1 uM/L is the 2nd day. The results reported here attest the active stability of substances and absence of resistance of the test-object Paramecium caudatum.