We explore molecular systems in a confined environment in order to learn about their chemical and physical properties, for instance in an on-surface adsorbed state (Figure 1). Thereby, scanning tunneling microscopy (STM) and atomic force microscopy (AFM) are suitable tools since they demonstrate real-space structure characterizations of molecules at the surface.[1,2] Understanding the subtle interplay between mechanics, surface commensurability and molecule dynamics at such ultimate level is also in the focus of the studies.  With combined STM/AFM technique it is possible to follow the on-surface formation of complex molecular architectures. A full atomistic description of different reaction products can be realized. The extent of control of reactivity and regioselectivity in aryl-aryl bond formation can be probed.[3]  The use of electrospray ionization technique to deposit large, complex and highly functionalized molecules under ultra-high vacuum conditions on substrates while keeping their structural integrity is of paramount importance.[4]  Fig.1. STM image of an assembly of tetraazaperylene molecules on Ag(111); sub-monolayer regime; T = 6 K; 2 nm scale bare in the inset.[1]