The article analyzes approaches to the study of Moldova-Russian relations in the context of the processes of European and Eurasian integration. The diversity of approaches in the study of the nature and prospects of Moldova-Russian relations in the context of integration processes offered by Western researchers and specialists from the post-Soviet space demonstrates a significant potential, both for common interests in bilateral relations and for the existing contradictions between Moldova and Russia. The influence on character and dynamics Moldova-Russian relations are provided by the format of cooperation between the Russian Federation and the European Union.