Studying the geopolitical architecture of the East-European space we can say that this part of the globe is in the process of formation as a result of relations am ong geopolitical actors – power centers – the West represented by the US, NATO and EU on one hand and on the other hand the Russian Federation. Carefully analyzing the ongoing transformations in East-European space, we see that the content of geopolitics centered on the ability of states to divide geo-graphical space has rapidly changed. This article analyzes for the first time the subject of the “new configuration of East-European geopolitical architecture”. Integration processes like the EU and NATO eastward extension, as well as those of integration / disintegration from post-Soviet space, the events in eastern Ukraine that resulted in the annexation of Crimea and the city of Sevastopol by the Russian Federation have had a significant influence on the creation of the new geopolitical architecture of the East-European space.