Molecular concepts of macrophage targeting
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BOLDESCU, Veaceslav; CRUDU, Valeriu; SUCMAN, Natalia; POGREBNOI, Serghei; ZVEAGHINŢEVA, Marina; STINGACI, Eugenia; POGREBNOI, Vsevolod; MACAEV, Fliur. Molecular concepts of macrophage targeting. In: Chemistry Journal of Moldova. 2013, nr. 2(8), pp. 21-31. ISSN 1857-1727.
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Chemistry Journal of Moldova
Numărul 2(8) / 2013 / ISSN 1857-1727 /ISSNe 2345-1688

Molecular concepts of macrophage targeting

DOI: 10.19261/cjm.2013.08(2).02
Pag. 21-31

Boldescu Veaceslav, Crudu Valeriu, Sucman Natalia, Pogrebnoi Serghei, Zveaghinţeva Marina, Stingaci Eugenia, Pogrebnoi Vsevolod, Macaev Fliur
 
Institute of Chemistry of the Academy of Sciences of Moldova
 
Disponibil în IBN: 26 februarie 2014


Rezumat

Macrophages play an important role in the pathological development of such disorders as cancer, inflammatory and certain infectious diseases, such as tuberculosis, HIV, dengue virus, and leishmaniasis. Therefore, macrophage targeting represents an important challenge in design of new medicines. This review gives a general presentation of small molecule-recognition concepts with application in drug design for macrophage targeting. It describes different mechanisms and systems for macrophage-targeted delivery, including ligands or small molecule motifs recognizable by macrophage specific proteins, like receptors (e. g. sialoadhesin, folate, galactose, mannose,β-glucan, and scavenger, tuftsin receptors) or enzymes (carboxylesterase-1), pathways for their obtaining and routes of their application.

Cuvinte-cheie
macrophage receptor targeting, macrophage enzyme targeting, inflammatory disorders,

tuberculosis,

cancer.