When we talk about discrimination, regardless of whether it is done in the context of the labor market or otherwise, it is considered a form of marginalization, the application of a differential, prejudicial treatment, receiving a negative connotation. Currently, numerous European legislative acts are dedicated to combating discrimination, being mainly focused on preventing discrimination based on nationality and sex, but not excluding race, ethnic origin, religion or religious beliefs, disability, age or sexual orientation. Starting from the European legislation in force, based on the statistical data provided by Eurostat, reports and case studies that focus on the issue of people with disabilities, this paper aims to reveal a brief picture of the current situation faced by people with disabilities on the labor market, as well as initiatives that can constitute good practice models related to the insertion and retention of these people on the labor market.