Non-clinical toxicity and phytotoxicity of two herbal extracts
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ANCUCEANU, Robert, ZBÂRCEA, Cristina Elena, COJOCARU-TOMA, Maria, CALALB, Tatiana, ANGHEL, Adriana-Iuliana, NEGREŞ, Simona, DINU, Mihaela, HOVANET, Marilena. Non-clinical toxicity and phytotoxicity of two herbal extracts. In: Farmacia, 2016, nr. 5(64), pp. 763-769. ISSN 0014-8237.
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Farmacia
Numărul 5(64) / 2016 / ISSN 0014-8237

Non-clinical toxicity and phytotoxicity of two herbal extracts


Pag. 763-769

Ancuceanu Robert1, Zbârcea Cristina Elena1, Cojocaru-Toma Maria2, Calalb Tatiana2, Anghel Adriana-Iuliana1, Negreş Simona1, Dinu Mihaela1, Hovanet Marilena1
 
1 University of Medicine and Pharmacy “Carol Davilla”, Bucharest,
2 ”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
Disponibil în IBN: 19 iunie 2022


Rezumat

Two herbal extracts, one of Panax notoginseng (Burkill) F. H. Chen and the other from oat bran were tested for their toxicity in NMRI mice, Artemia franciscana Kellogg and for their phytotoxicity on Triticum aestivum L. No lethality was recorded and no changes in the parameters followed up were seen for any of the two extracts tested on mice. Based on the experimental data the two extracts may be classified in the Globally Harmonized System (GHS) category 5. In the Artemia test, the Panax notoginseng extract was virtually non-toxic (0% lethality); the oat bran extract had slight toxicity, but for all practical purposes it may also be considered non-toxic. In the Triticum test a concentration-dependent inhibitory effect on root elongation (p < 0.001), was seen at concentrations of 0.5% and higher (p < 0.001% versus control) in the case of Panax notoginseng and at concentrations of 0.25% for the oat bran extract (p < 0.012); the results are in agreement with those seen on Artemia franciscana. 

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