The intensification of globalization is a preliminary and very important step in supporting cross-border cooperation between neighboring states and regions with a common border. This article addresses cross-border issues, in particular those related to cross-border security and its impact on the sustainable development of the world's countries, the impact of national issues on neighboring states and other international states. The article identified cross-border issues that could affect the international economy and proposed measures to mitigate their negative effects to as to address the common challenges identified by Member States in border regions and exploit their untapped growth potential.