The purpose of these studies was to analyze the content of the main macronutrients of the soil C, N, P, K. The research was carried out in a long-term (from 1953) stationary experiment with different fertilizer and crop types on Calcareous Chernozem (Calcic chernozem in the World reference base for soil resources). Macronutrient dynamics associated with fertilizer rate and residue application were determined. There is a significant decrease in nutrient content compared to the original content when the experiment was set up in 1953.