Root rot is considered one of the most common diseases in crop plants, including the common winter wheat Triticum aestivum L. The disease is caused by various soil pathogens, among which Fusarium fungi are noted with advanced incidence and severity. These pathogens reduce plant biomass due to obstruction of water and nutrients entry into the plant. As research material served: 1) common autumn wheat grains of 2 genotypes – L SBS and L M / M3); 2) culture filtrate (CF) of the fungus Fusarium oxysporum; 3) vinyl-triazolic derivative ((z) -1- (2,4dichlorophenyl) -5-methyl-2- (1h-1,2,4-triazol-1-yl) hex-1-en-3- one) – EPS 165 in concentrations of 0,005 and 0,01%. CF F. oxysporum was prepared by inoculating the fungal mycelium into the liquid nutrient medium Cszapek. The wheat grains well selected on the basis of uniformity and size were treated for 3 hours with the emulsion of the mentioned compound in concentrations of 0,005 and 0,01%, after which they were dried in the open air at room temperature for 48 hours. The emulsion of the preparation was obtained by adding dimethylsulfoxide of 9%, TWIN-80 emulsifier of 20% and ethanol of 70% to the investigated compound, taken in a concentration of 1%. Wet grains soaked in distilled water for 18 hours served as control I, and grains soaked in CF F. oxysporum for 18 hours served as control II. The outdoor dry mass per plant (mg), determined by weighing, was used as a criterion for resistance/sensitivity to the pathogen. The results obtained are presented in the table bellow. Table. Influence of study variants on the dry biomass of wheat seedlings at their interaction with F. oxysporum (SBS Line) Nr. Variant Dry biomass per plant, mg ζ In comparison to Control II, % 1 H2O – Control I 10,77±0,39 0,68 137,9 2 CF F. Oxysporum – Control II 7,81±0,23v 0,39 3 Compound EPS165- 0,01% + CF F. Oxysporum 10,65±0,06* 0,10 136,36 4 Compound EPS165- 0,005% + CF F. Oxysporum 10,31±0,04* 0,07 132,01 *- statistically significant difference in relation to ―CF F. oxysporum‖, p≤0.05. – v- statistically significant difference in relation to ―Control I‖, p≤0.05. According to the data from the table, the treatment of common winter wheat grains with compound EPS 165 in concentrations of 0,01- 0,005% leads to an increase in the amount of dry biomass in comparison to the control- F. oxysporum by 32,01-36,36%.