Resin acids as raw material for fabrication of antifungal micro- and nanoparticles of dehydroabietic acid loaded with cyclodextrin and chromenol hybrid
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2023-10-29 09:07
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54.06:547.914 (1)
Analiză, investigae și manipulare în general (25)
Chimie organică (475)
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ZVEAGHINTSEVA, Marina, STYNGACH, Evgenia, POGREBNOI, Serghei, LUPAŞCU, Lucian, VALICA, Vladimir, UNCU, Livia, KRAVTSOV, Victor, TERTEAC, Dumitru, BRÎNZAN, Alexandru, MAKAEV, Fliur. Resin acids as raw material for fabrication of antifungal micro- and nanoparticles of dehydroabietic acid loaded with cyclodextrin and chromenol hybrid. In: Ecological and environmental chemistry : - 2022, Ed. 7, 3-4 martie 2022, Chișinău. Chisinau: Centrul Editorial-Poligrafic al USM, 2022, Ediția 7, Vol.1, p. 165. ISBN 978-9975-159-07-4.. 10.19261/eec.2022.v1
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Ecological and environmental chemistry
Ediția 7, Vol.1, 2022
Conferința "Ecological and environmental chemistry 2022"
7, Chișinău, Moldova, 3-4 martie 2022

Resin acids as raw material for fabrication of antifungal micro- and nanoparticles of dehydroabietic acid loaded with cyclodextrin and chromenol hybrid

CZU: 54.06:547.914

Pag. 165-165

Zveaghintseva Marina1, Styngach Evgenia1, Pogrebnoi Serghei1, Lupaşcu Lucian1, Valica Vladimir2, Uncu Livia2, Kravtsov Victor3, Terteac Dumitru14, Brînzan Alexandru4, Makaev Fliur12
 
1 Institute of Chemistry,
2 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
3 Institute of Applied Physics,
4 Practical Scientific Institute of Horticulture and Food Technology
 
Proiecte:
 
Disponibil în IBN: 16 martie 2022


Rezumat

In these presentation methods to fabricate micro- and nanoparticulate systems from dehydroabietic acid and βcyclodextrin with chromenol-triazol hybrid will be reported. Kneading, co-evaporation and co-precipitation as example of the resolution technology of racemic chromen-2-ol for obtaining micro- and nanoparticles has optimized. The inter- and intra-molecular interactions among ingredients were characterized by X-Ray, IRand NMR spectroscopies. The antifungal activity data of the obtained systems will be discussed. It was been shown that β-cyclodextrin microparticulate systems loaded with dehydroabietic acid and chromenol-triazol hybrid are as effective as pure components applied in higher dosages.