The relevance of the study is explained by the need to find ways to adapt the existing mechanisms for managing economic security to the realities of the development of the external and internal environment for the functioning of business entities. This primarily concerns industrial enterprises, which are especially influenced by the trends of Industry 4.0. Rebuilding production processes requires the modernization of all management processes, including the process of economic security management. Purpose. The aim of the study was to determine the necessary directions for the adaptation of mechanisms for managing the economic security of industrial enterprises to ensure effective counteraction to the risks of Industry 4.0. Research methods. The research methods were theoretical analysis and content analysis of materials devoted to the problems of strategic management and economic security management, as well as the generalization method, which was used to develop the author's proposals and conclusions based on the results of the research conducted. Results. The problems of functioning of industrial enterprises in the conditions of the spread of Industry 4.0 and possible risks for the state of their economic security in a strategic perspective are identified. Proposals were made regarding the transformation of the structure and functioning of the mechanism for managing economic security in new conditions for enterprises.