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SM ISO690:2012 UNCU, Livia, EVTODIENCO, Vladilena, MAZUR, Ecaterina. Validation of the spectrophotometric method for the dosing of some combined capsules. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 446. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Pag. 446-446 | ||||||
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Rezumat | ||||||
Background. UV spectrophotometry remains the most accessible spectral method, with a high degree of sensitivity and informativeness. The advantage of the method consists in its universality, the ability to combine with other methods, the minimum error, as well as its economic efficiency. Objective of the study. Determination of some validation parameters for the spectrophotometric method of dosing piracetam and nicergoline in combined capsules. Material and Methods. Agilent 8453 UV-VIS spectrophotometer, standard samples of piracetam and nicergoline, 0.1 M HCl methanolic solution. Validation of the spectrophotometric method according to the provisions of the ICH guide “Q2R1: For analytical procedures and validation”. Results. Linearity was investigated on concentration ranges 5-40 μg / ml. The r2 values were 0,9998 for nicergoline and 0,998 for piracetam, respectively. The limit of detection was 1,737 μg / ml for nicergoline and 0,369 μg / ml for piracetam. Quantification limit values were also calculated as 5,265 and 1,118 μg / ml for nicergoline and piracetam accordingly. The results obtained showed that the spectrophotometric method developed is accurate, precise and robust, because the value of the standard deviation was less than 1,0%. Conclusion. The developed spectrophotometric method has specificity, linearity, accuracy, precision and robustness, and can be applied on the concentration range between 80-120% of the nominal value of the content of nicergoline and piracetam in the preparation |
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Cuvinte-cheie quantitative determination, spectrophotometry, validation, determinare cantitativă, spectrofotometrie, validare |
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