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SM ISO690:2012 ELADI, Veronica, TONTICI, Ecaterina, LEAHU, Alina, ROTARU-COJOCARI, Diana, RAŞCOV, Victor, SELEVESTRU, Rodica, ŞCIUCA, Svetlana. Primary ciliary dyskinesia in children. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 388. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Pag. 388-388 | ||||||
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Rezumat | ||||||
Background.Primary ciliary dyskinesia (PCD) is a rare congenital disease characterized by defective ciliary function of respiratory tract epitheliocytes, which affects mucociliary clearance and contributes to recurrent and chronic upper and lower respiratory tract infections. Objective of the study. Elucidation of clinical signs and exploratory criteria for ciliary dyskinesia in children. Material and Methods. There are 3 confirmed cases of DCP confirmed in the Pneumology Clinic of the Mother and Child Insitute. Patients were investigated by ECG, pulmonary radiography, pulmonary computed tomography (CT), saccharin test. Of these children with DCP, two have Kartagener syndrome (sinusitis, bronchiectasis and situsinversus). Results. Morbid history of persistent wet cough with mucopurulent sputum, nasal voice and difficult nasal breathing. In 2 patients, imaging examination confirmed complex inverse situs. Radiography of the paranasal sinuses showed signs of pansinusitis in all children in the study. Imaging research by pulmonary CT showed signs characteristic of chronic broncho-pulmonary processes: varicose and sac-shaped bronchiectasis, tractionbronchiectasis, pleuro-pulmonary adhesions, fibro-atelectatic areas in various segments. The spirometric functional examination confirmed in these children the presence of restrictive and obstructive disorders of moderate and severe degree. Conclusion. Disorders of mucociliary clearance in children with ciliary dyskinesia due to frequent respiratory infections lead to chronic rhinosinusal and pulmonary processes with the formation of bronchiectasis, fibroelectasis. |
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Cuvinte-cheie Primary ciliarydyskinesia, Kartagener syndrome, situsinversus, dischinezie ciliară primară, Sindrom Kartagener, situs inversus, copii |
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