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SM ISO690:2012 SOCHIRCĂ, Marcel, CULIUC, Vasile, CASIAN, Dumitru, GUTSU, Eugene. Blood group and the risk of the development of posttrombotic syndrome. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 273. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Background. Postthrombotic syndrome (PTS) is common sequelae after deep vein thrombosis (DVT) of the lower extremities, with a number of widely recognized risk factors. However, recent studies have revealed an inhomogeneous rate of occurrence of PTS depending on the patient's blood type. Objective of the study. The aim of the present research was to compare the frequencies of PTS occurrence in patients with a medical history of DVT, considering belonging to blood groups O (I) or non-O (II, III, IV). Material and Methods. The study group included 218 inpatients (222 limbs) hospitalized for DVT and subsequently evaluated over 72 (25%-75% IQR 36-96) months after the thrombotic episode. Average age per cohort at hospitalization – 57.93±14.9 years. DVT was confirmed by duplex scanning, while the Villalta score was used to define PTS. The blood groups were assigned according to the ABO system. Results. According to LET classification of DVT the observations were distributed as follows: class I (0.85%), II (51.5%), III (41.63%) and IV (6%). Towards the follow-up period, two subgroups of subjects were identified – with (n=144) and without (n=78) PTS. The rate of patients with blood group O (I) in the PTS subgroup was only 7.31%. Conversely, among subjects without PTS, blood group O (I) was determined in 1/3 of cases (P=0.0089; χ2 test). Up to 73.07% of patients with DVT who had blood groups A (II), B (III) or AB (IV) later developed PTS. Consequently, the relative risk of “non-O blood groups” factor was shown to be 2.43 (95% CI 1.03-6.36). Conclusion. Our data support the assumption that in patients with DVT the blood group according to ABO system interferes with the rate of subsequent occurrence of PTS. Belonging to non-O blood groups appears to be a risk factor for PTS, but additional studies are needed to confirm the conclusion. |
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Cuvinte-cheie blood group, thrombosis, postthrombotic syndrome, grupă sangvină, tromboză, sindrom posttrombotic |
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