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SM ISO690:2012 BEREZOVSKAIA, Elena, LUPAŞCO, Iulianna, DUMBRAVA, Vlada-Tatiana, POSTOLATI, Galina. Peculiarities of amino acid metabolism in patients with chronic viral hepatopathies. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 135. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | |||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | |||||
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Pag. 135-135 | |||||
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Rezumat | |||||
Background. Chronic viral hepatopathy (CVH) present one of the most important problems in contemporary medicine. It is known that chronic liver disease causes various types of metabolic disorders and, consequently, affects the change in the amino acid composition of the body. Objective of the study. The aim of this study was to evaluate the levels of glycine, serine and glutamic acid in the blood serum in patients with chronic viral liver disease. Material and Methods. To achieve this goal, the levels of glycine (Gly), serine (Ser) and glutamic acid (Glu) were determined in 10 patients of CVH of HBV etiology and in 10 apparently healthy people (HP). The of amino acids level was made using liquid chromatography. Results. It was found that the level of Glu, Ser and Gly in patients with CVH is significantly lower (p<0.05)than in HP: Gly 0.165±0.014 mmol/L vs 0.218±0.018, Ser 0.074±0.006 mmol/L vs 0.124 ± 0.028 and Glu 0.060±0.008 mmol/L vs 0.117±0.015 in HP, consequently. Given the fact that Glu, Ser and Gly are essential proteinogenic amino acids that are involved in the synthesis of carbohydrates, proteins and other types of metabolism, as well as Glu and Gly are some of the neuromediators and neurotransmitters of the CNS, low levels of Glu, Serum and Gly may indicate metabolic disorders and serve an indirect confirmation of the affected functional state of the liver and CNS. Conclusion. In patients with CVH of HBV etiology, metabolic disorders and decreased levels of some CNS neuromediators and neurotransmitters are observed. However, it is necessary to continue the study on a larger sample and to evaluate the content of other amino acids in patients with CVH |
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Cuvinte-cheie Chronic viral hepatopathy, amino acids, metabolic disorders, hepatopatii cronice virale, aminoacizi, tulburări metabolice |
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