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SM ISO690:2012 PODUREAN, Mariana, ŞTEFANEȚ, Olga, TĂBÎRȚĂ, Victoria, OLARU-STĂVILĂ, Cătălina, BERLIBA, Elina. Clinical and demographic characteristics among patients with alcoholic hepatitis. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 111. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Pag. 111-111 | ||||||
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Rezumat | ||||||
Background. Alcoholic hepatitis (AH) is the most severe manifestation of alcohol associated liver disease with a high rate of morbidity and mortality. It is paramount to establish a screening method with reasonable accuracy in assessing cases with high risk of developing terminal liver disease alcohol-induced. Objective of the study. Analysis of demographic and clinical characteristics of patients with AH and observational study of risk factors involved in development of alcohol induced end stage liver disease. Material and Methods. In this observational study, it was researched retrospectively 61 patients with AH admitted in Department of Hepatology of SCR “T. Moșneaga”. The diagnosis of AH was confirmed clinically by questionnaire (AUDIT C),anamnesis with supporting laboratory findings. Assessment of liver function and Maddrey discriminant factor (MDF) was calculated at presentation. Results. The highest frequency was in young adults, the average age of patients being 54 ± 10.1 years (33-73), with male prevalence (55.73%). But women were more likely to develop a severe form of AH (48.65%), using a smaller amount of alcohol. The habit of binge-drinking was determined in 62.29% of patients. The most important clinical manifestations were: asthenic syndrome (96.72%), jaundice (75%), ascites (47.54%), hemorrhagic syndrome (31.14%), hepatic encephalopathy (29.95%). The death rate among patients with AH was 24.32%, all with MDF> 32, predominantly females (56.8%). Conclusion. The amount of alcohol, gender, habit of consumption are risk factors for severe alcoholic disease and patients with MDF> 32 develop more frequent complications and have a poorer outcome. Creating a screening system in this regard will help reduce mortality rat |
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Cuvinte-cheie Alcoholic hepatitis, risk factor, Maddrey discriminant factor, hepatită alcoolică, factori de risc, scor Maddrey |
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