Articolul precedent |
Articolul urmator |
461 22 |
Ultima descărcare din IBN: 2024-04-01 18:05 |
SM ISO690:2012 OSTAP, Felicia, BORŞ, Eleonora. Role of epicardial adipose tissue in the pathogenesis of atrial fibrillation. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 42. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Background. Clinical studies revealed the correlation between epicardial fat volume and atrial fibrillation risk.This fat depot located between the myocardium and the visceral pericardium, due to the proximity to the myocardium, can contribute to the formation of an arrhythmogenic substrate. Objective of the study. To describe the mechanisms through which epicardial adipose tissue is involved in the pathogenesis of atrial fibrillation. Material and Methods. In order to carry out the literature review, articles published in the last five years were analyzed. The search in the Pubmed database was performed using the following keywords: atrial fibrillation, epicardial adipose tissue. Results. Epicardial adipose tissue secretes a series of bioactive factors called adipokines which act in a paracrine or vasocrine way meanwhile, it represents a source of reactive oxygen species. Under certain pathological conditions, such as obesity, epicardial adipose adopts a secretome dominated by proinflammatory mediators like IL-1β, IL-6 and TNFα, and profibrotic factors such as activin A-member of TGF-β, as well as matrix metalloproteinase. The lack of an anatomic fascia between this adipose tissue depot and the myocardium makes possible the fatty infiltration of the atrial myocardium, which combined with fibrosis generates conduction abnormalities. Conclusion. Increased epicardial adipose tissue volume represents a risk factor for atrial fibrillation, which suggests the potential utility of its quantification using imaging techniques. Inflammation, fibrosis, and fatty infiltration are some of the mechanisms that explain this association. |
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Cuvinte-cheie atrial fibrillation, epicardial adipose tissue, fibrilația atrială, țesutul adipos pericardic |
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