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SM ISO690:2012 COLIN, Mihail, TIMERCAN, Tatiana. Diseases associated with the oxidative decarboxylation of pyruvate. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 37. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Pag. 37-37 | ||||||
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Background. The oxidative decarboxylation of pyruvate represents a complex biochemical process. The final product Acetyl-Co-A, is an essential substrate used in various metabolic paths of vital singnificance. Errors in the functioning of this biochemical process generate dangerous patho-metabolic consequences. Objective of the study. Establishing the interdependence between the altered functioning of the dehydrogenase pyruvate complex and the metabolic and tissue manifestations. Material and Methods. Recent publications from electronic journals database as PubMed and ScienceDirectwere selected and examined. Results. The obtained data showed an interrelation between PDHA1 gene mutations that provide instructions for the biosynthesis of the alpha subunit of the PDH enzyme and the decrease in pyruvate oxidative decarboxylation activity. Therefore, the decrease of the functionality of the multienzyme complex PDH, provoke the preferential conversion of pyruvate into lactic acid, which leads to the induction of a pathological state of metabolic acidosis, as well as the decrease of Acetyl-Co-A use in the Krebs' cycle. Lack of PDH causes energy-metabolic deficiencies, distrupting the integrity of nerve tissue, also causing pathological osteo-muscular development of the visceral region of the skull. Conclusion. The multienzyme complex pyruvate dehydrogenase plays a crucial role in the functionality of the oxidative decarboxylation of pyruvate.Thus, PDHA1’s impartial gene expression disrupts pyruvate metabolism, inducing several damages to various tissues. |
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Cuvinte-cheie PyruvateDehydrogenase, pyruvate’smetabolism, PDHA1, Piruvat Dehidrogenaza, metabolismul piruvatului, PDHA1 |
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