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SM ISO690:2012 MELINTE, Mihaela, DUMITRAŞ, Grigorie. Synergistic effect of obesity on the lymphatic system. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 24. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Pag. 24-24 | ||||||
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Rezumat | ||||||
Background. The lymphatic system is a component of the cardiovascular system, it plays an important role in fluid homeostasis, macromolecules transport, regulation, and modulation of the immune response, as well as in fat absorption and cholesterol metabolism. Objective of the study. Review of the scientific literature on morphology and changes of the lymphatic system in obesity. Material and Methods. 20 articles from the Pubmed, CrossRef databases were analyzed using the search words "lymphatic vessels in obesity", "lymphatics in adipose tissue". Results. Experimental studies have shown that in obese mice there is a decreased density of lymphatic vessels in subcutaneous adipose tissue, reduced proliferation of endothelial lymphatic cells, and decreased clearance of macromolecules. The lymph nodes are also changed with T lymphocyte damage. Histopathological examination of the normal weight and obese mice revealed that lymph vessel dysfunction caused by obesity increases the degree of inflammation and deposition of adipocytes. Conclusion. The interdependent relationship between obesity and lymphatic dysfunction is currently being demonstrated. The perception of these mechanisms would allow the regulation of lymphatic functions and the development of a treatment that will have a major impact on obese patients. |
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Cuvinte-cheie Lymphatic dysfunction, obesity, adipocytes, Disfuncție limfatică, obezitate, adipocite |
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