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Articolul urmator |
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SM ISO690:2012 CAZACU, Eugeniu, PRETULA, Ruslan, MĂRIȚOI, Tatiana. Histological and immunohistochemical study of 2 cases of deep soft tissue leiomyoma. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 20. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Pag. 20-20 | ||||||
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Background. The low incidence of deep soft tissue leiomyoma, the absence of signs and symptoms of onset in most cases are important problems in attempts to detect the disease early. Objective of the study. The aim of our study is to help elucidate aspects related to tumor pathogenesis and immunohistochemical profile underlying the tumor. Material and Methods. The studied material was represented by the operating parts from the Department of Pathology of the SCR Timofei Moșneaga. The methods used were paraffin inclusion technique and immunohistochemical techniques for assessing the origin and exclusion of a malignant process and its confirmation by the following markers Ki67, EMA, PCK, CD34, SMA, Desmin, Vimentina, S100, Melanosome HMB45, ER, PR. Results. The expression of all these markers on smooth muscle cells in both the normal myometrium and leiomyomas suggests their involvement in uterine functions through autocrine / paracrine mechanisms, directly stimulating tumor growth and progression. Conclusion. The evaluation of the tumor immunoprofile, in correlation with the data from the literature on the significance of tumor markers could be an indicator of the mixed origin of deep leiomyomas. |
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Cuvinte-cheie histological, immunohistochemical, deep leiomyoma, histologic, imunohistochimic, leiomioame profunde |
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