The paradox of changing the sleep architecture in administration of hypnotics
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COJOCARU, Victor; BODNARI, Maria; LUPUŞOR, Adrian. The paradox of changing the sleep architecture in administration of hypnotics. In: World Sleep Congress. Ediția a 14-a, 7 octombrie - 11 noiembrie 2017, Prague. Prague, Czech Republic: World Sleep Society, 2017, p. 199.
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World Sleep Congress
Ediția a 14-a, 2017
Congresul "World Sleep Congress"
Prague, Czech Republic, 7 octombrie - 11 noiembrie 2017

The paradox of changing the sleep architecture in administration of hypnotics

CZU: 612.821.7:615.214.24

Pag. 199-199

Cojocaru Victor, Bodnari Maria, Lupuşor Adrian
”Nicolae Testemițanu” State University of Medicine and Pharmacy
15.817.04.51A Cercetarea multidimensională a tulburărilor de mişcare şi fenomenului algic cu elaborarea metodelor terapeutice non-farmacologice
Disponibil în IBN: 22 noiembrie 2021


Introduction: According to unofficial data, in the Republic of Moldova, hypnotics are the first line treatment for insomnia. According to literature data, these drugs alter the normal sleep structure. Thus, hypnotic-induced sleep will have lower latency and it will be longer, but with altered structure. Moreover, hypnotics cause addiction, tolerance and do not treat the causes of insomnia. Materials and methods: A series of cases have been analyzed. From the database of the Center of Somnology within the Institute of Neurology and Neurosurgery, 11 patients with insomnia were researched with cardiorespiratory polymorphism with neuroport, who had already administered hypnotics from the benzodiazepines group and/or non-benzodiazepines, by the time they addressed. Results: According to hypograms, sleep efficiency was down to 64% of patients and sleep latency went up to 50%. At the same time, 50% of patients suffered an increase in phases 1 and 2 (NREM), and 91% had the third phase of NREM sleep diminished compared to normal; half of patients recorded a sleep with rapid eye movement (REM) within the normal range. Hypnogram analysis revealed changes in the ratio between sleep stages: superficial sleep was increased and the slow wave sleep, diminished. Reduced sleep efficacy and increased sleep latency denote the low efficacy of hypnotics in the treatment of insomnia of the studied cases. Conclusions: The use of hypnotics for treating the insomnia as a single and first-line method does not produce the desired effect. In addition, they alter the architecture of sleep and induce a superficial, respectively nonqualitative sleep. The treatment of insomnia requires a complex approach: drug treatment should complete the non-medication methods aimed to solve the causes of insomnia.