The article presents a general description of the demographic situation in the Republic of Moldova at the beginning of the XXI century (negative population growth), a comparative analysis with the previous period is carried out, the main factors contributing to the deterioration of demographic indicators are analyzed: a decrease in the birth rate, an increase in mortality rates – causes and effects, migration outflow of the population of working and reproductive age, negative tendencies in nuptiality (reduction in the number of marriages, postponement of marriages to a later date, a sharp increase in the number of divorces), deterioration in the health of the population, reduction in life expectancy. In general, the deterioration of demographic indicators is a consequence of political instability, a high level of corruption, a severe economic crisis, resulting in the decline of living standards, increase of unemployment, degradation of social security systems, education, culture, science, etc. All these negative processes were reflected in the Ukrainians of Moldova. The most compact Ukrainians live in the northern regions and on the left bank of the Dniester, which is due to historical factors.