The European intercultural context, especially in the current pandemic, requires the acceleration of modernization of the system of ensuring human security and safety by re-conceptualizing the personal security of the individual, as well as the culture of security and safety. In this context, the concept of human security was developed in direct connection with the theory of the society at risk, in which special role is given to the security of the person. The Republic of Moldova (RM) interacts at institutional, normative, value, civilizational level with the European intercultural space in the format determined including by the Association Agreement of the RM with the EU, signed on June 27, 2014. The priorities of the Agreement are related to the specifics of the Moldovan society, to its modernization needs. Therefore, the sustainable development of the RM, as part of the European space, with new values and perspectives determines a revaluation of the individual’s primary needs, including the need for personal safety and security and for an easier intercultural dialogue in a European intercultural space meant to become a stronghold of harmony, security, development and prosperity.