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SM ISO690:2012 TELEATNIC, Nicoleta, MOLDOVANU, Ion. The relationship between chronic pain and structural and fuctional changes in the corticolimbic system. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 216. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | |||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | |||||||
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Background. Chronic pain affects 10%-20% of the Earth's population being considered a global health problem due to its cost and major impact on patients' quality of life.The corticolimbic system is involved in the chronitization of pain. Objective of the study. Determination of the correlation between structural and functional changes of the corticolimbic system and chronic pain. Material and Methods. An analysis of 53 articles was performed, published between 2017-2020 using the NCBI database. Results. This study provides evidence of changes in the brain in both structural and functional MRI studies. Structural MRI studies indicated a lower volume of gray matter in patients with chronic pain compared to controls. In 10 of 15 studies, a decrease in the volume of global or regional gray matter was found, including the dorsolateral prefrontal cortex, the island, the temporal lobes, the cuneus, the thalamus, the medial prefrontal cortex, and the posterior cingulate cortex. In fMRI studies, people with chronic pain showed increased activity and altered connectivity during resting state, especially in the default mode network, as well as during attention tasks. Conclusion. Patients with chronic pain have neuroplastic changes in many areas of the brain. Changes in the corticolimbic system influence the cognitive and emotional components of chronic pain contributing to its amplification. |
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Cuvinte-cheie chronic pain, corticolimbic system, structural MRI studies, fMRI, durere cronică, sistemul corticolimbic, studii RMN structurale, fRMN |
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