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Articolul urmator |
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Ultima descărcare din IBN: 2023-12-05 19:23 |
SM ISO690:2012 PETROV, Mihaela, OPREA, Valentin. Contemporary treatment in schizophrenia (atypical antipsychotics). In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 214. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Background. The current treatment of schizophrenia is based on the dopaminergic hypothesis, there are approaches that involve new signaling mechanisms on the classic drug targets or completely new targets. Schizophrenia with a heterogeneous etiology includes patients with a varied response to treatment. Objective of the study. Study of the efficacy of schizophrenia therapy with various atypical antipsychotics, determination of the frequency and efficiency of the use of atypical neuroleptics in patients with schizophrenia. Material and Methods. Statistical data processing was performed by the questionnaire method to achieve the purpose of the study. The analysis of the efficacy of the administered antipsychotic treatment was evaluated using the CGI (Clinical Global Impression) scale. The results of the study were subjected to a computerized mathematical analysis using the STATISTICS 7.0 software package. Results. The most common antipsychotic combinations include olanzapine or clozapine and are the neurobiological approach to facilitating the blockade of additive and complementary dopaminergic receptors by sulpiride or amisulpride. The most commonly used atypical neuroleptics were risperidone 55%, followed by clozapine 38%, aripiprazole 3%, quetiapine 3% and olanzapine 1%. Most patients (74.6%) received more than 1 psychotropic drug. In 21.4% of cases, "polypragmatism" was found, being administered >4 psychotropic drugs (neuroleptics, benzodiazepines, barbiturates, antiparkinson drugs) per patient. Conclusion. The analysis on the efficacy of the antipsychotic treatment demonstrated that the patient's satisfaction with atypical therapy is clearly superior to the typical one. Atypical antipsychotics have greatly improved the treatment of schizophrenia with a considerable decrease in side effects |
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Cuvinte-cheie atypical antipsychotics, efficiency, Tolerability, schizophrenia, neuroleptice atipice, eficacitate, tolerabilitate, schizofrenie |
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