The confectionery sunflower hybrid breeding objectives are complicated because of the need to combine several specific traits in one genotype, which is ensured by a successful combination of parents of a hybrid. Assessment the combining ability of self-pollinated lines significantly increases the efficiency of search for the best hybrid combinations. A three-year study was conducted in the scientific crop rotation fields of the Plant Production Institute named after V.Ya.Yuriev of NAAS (Eastern Left Bank Forest-Steppe of Ukraine). We studied 10 self-pollinated lines with different characteristics and 90 hybrid combinations obtained by the complete diallel crossing design (♀10 × ♂10). The experimental hybrids and parental lines were sown with a density of 20,000 plants per hectare. We assessed the following features: 1000-seed weight (g), seed yield (t/ha), huskness (%), oil content in kernels and in seeds (%), and protein content in kernels (%). Lines – pollen sterility fixers Kh 51 B, Kh 72 B, Kh 75 B, and line – pollen fertility restorer Kh 2301 V were distinguished as large-seeded (1000-seed weight  80 g) and high-protein (up to 26%). There were significant differences between the lines in the effects of the general combining ability (GCA) and the constants of the specific combining ability (SCA). Lines – pollen sterility fixers Kh 51 B, Kh 72 B, Kh 75 B Kh 63 B, and line Kh 2301 V, with high and year-to-year stable GCA effects, were distinguished due to the 1000-seed weight in their hybrids. These lines were evolved from varieties-populations of the collection of the National Center for Plant Genetic Resources of Ukraine, such as Kharkovskiy 7, Zaporozhskyi Konditerskiy, Lakomka, Bogucharets. Lines - pollen sterility fixers Kh 51 B, Kh 59 B, Kh 75 B, Kh 1002 B were distinguished due to high and stable yields from their hybrids. The lines showed significant differences in the SCA constants, which made it possible to select highly heterotic hybrid combinations of These assessments allow further targeted use of the lines. From the lines with a high combining ability, confectionery hybrids Hudvin, Nasoloda, Kosmos, which are included in the State Register of Plant Varieties Suitable for Dissemination in Ukraine, as well as promising hybrid combinations, have been derived.