Purpose: underline and argumentation of importance for creating of crop varieties with stability, sustainable productivity and tolerance to seasonal shifts, climate stress factors. In order to estimate the response and screening the genotypes has been realized the evaluation of germplasm sensitivity to abiotic stress for cereal crops, legumes, vegetables (tomatoes). To identified the sensible varieties under stressful environmental conditions (drought, heat, cold) were applied biotechnological processes (gametic/sporophytic screening) and statistical methods of quantitative genetics. According to the definition given by Climate Essentials (2019), climate resilience means the ability to recover from and adapt to the impacts of climate changes. Climateresilient crops means of adapting diminishing yields to drought, higher average temperatures and other climatic conditions associated with abiotic stress factors. Crop resilience, stability and productivity are needed to endure increasingly frequent climatic stress. For the most part, cultivar stability is not associated with productivity, and it is negatively related with disease resistance, while resilience is negatively associated with productivity. Resilience is the ability to withstand a short‐term crisis, perturbation, or shock, like a drought, by absorbing the perturbation and reorganizing to retain the same function, also referred as resistance, and robustness. By our researches it was demonstrated that abiotic stresses, such as drought, heat or cold trigger a series of responses in plants that include changes in antioxidant enzymes activities, quantitative traits expression, as well as cumulative manifestations to biotic factors (fungi and viruses), that adversely affect and limit plant growth and crop productivity. Based on the evaluation the reaction of crop plants on stress background created by water deficit and extreme temperatures were realized gametic, sporophytic selection with different reactivity; elucidated the role of the parental factor, year as a source of variation of agrobiological traits; established the genetic control of the variability of the productivity elements; selected the genotypes with resistance to extreme abiotic factors. Given the considerable climatic fluctuations, it is necessary to promote a sustainable system, which aims to create genotypes resistant to a complex of extreme factors. Climate resilient crop varieties along with other suitable strategies will help to overcome the negative impact of climate change by lowering the yield losses under stress conditions.