Aim: to assess the correlation between SLEDAI (disease activity scoring system), SLICC (The Systemic Lupus International Collaborating Clinical/American College of Rheumatology Index) with different disease manifestations (major organ involvement: cardiovascular, pulmonary, renal), vasculitis, APS (antiphospholipid syndrome), dyslipidemia, hypertension, risk of cancer and survival. Methods: An observational, retrospective study of the last decade (01.05.1998 – 01.05.2008) was carried out in the University Clinic of Rheumatology Tirgu Mures (Romania). A total of 77 patients were enrolled. The data were issued from the charts files. Survival was determined from the time of diagnosis. The causes of death issued from the charts files were not always backed-up by postmortems (family refusal). Statistically a Kaplan Meyer analysis (using non parameters tests) and the Pearson Correlation were performed using GraphPadPrism5. Results: Mean age was 42.96±12.93 and the mean duration of the disease was 6.701±5.847 years. A positive powerful association was observed between SLICC and SLEDAI (Pearson r = 0.7079, 95%CI: 0.5750 to 0.8043, p< 0.0001). Positive correlations were obtained between SLEDAI and cardiovascular involvement (Pearson r = 0.2515, 95%CI: 0.02914 to 0.4502, p=0.0273), pulmonary involvement (Pearson r = 0.2433, 95%CI: 0.02041 to 0.4432, p=0.0330), renal involvement (Pearson r = 0.3527, 95%CI: 0.1397 to 0.5345, p=0.0017) and death (Pearson r = 0.2887, 95% CI: 0.06911 to 0.4816). Statistically we were unable to prove an association between the disease activity index and vasculitis (Pearson r = 0.1856, 95%CI: -0.04011 to 0.3933, p=0.1061), APS (Pearson r = 0.1755, 95%CI: -0.3844 to 0.05054, p=0.1269), hypertension (Pearson r = 0.05388, 95%CI: -0.1722 to 0.2746, p=0.6416) and dyslipidemia (Pearson r = 0.1399, 95%CI: 0.08688 to 0.3529, p=0.2250). The survival rate at 5 years was 94% versus the survival rate at 10 years - 86%. A statistical difference was obtained as to the survival of patients diagnosed with mild disease versus the ones diagnosed with severe disease (p=0.0434) in favor of mild disease. The causes of death for SLE were respiratory failure in 2 cases (one of them associated with severe sepsis), renal failure in 4 instances (one on chronic dialysis expired due to head trauma) and one case of disseminated breast carcinoma. Four patients were diagnosed with cancer (2 breast cancer, 2 ovarian cancers – 3 survived). Conclusions: For our patients SLEDAI and SLICC are good predictors for survival in SLE patients, but interestingly enough, hypertension and dyslipidemia didn’t correlate with outcome. This is to be further investigated.